Publications

Click here for a full list of publications from PubMed

2016

Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Hardaway JA, Jensen J, Kim M, Mazzone CM, Sugam JA, Diberto JF, Lowery-Gionta EG, Hwa LS, Pleil KE, Bulik CM, Kash TL. Behav Brain Res. 2016 Jul 1;307:25-34.

Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL. Cell Rep. 2016 Mar 16. pii: S2211-1247(16)30204-2. 

Mu Opioid Receptor Modulation of Dopamine Neurons in the Periaqueductal Gray/Dorsal Raphe: A Role in Regulation of Pain.
Li C, Sugam JA, Lowery-Gionta EG, McElligott ZA, McCall NM, Lopez AJ, McKlveen JM, Pleil KE, Kash TL. Neuropsychopharmacology. 2016 Jan 21. 

2015

Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward. Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CM, Crowley NA, Krashes MJ, Lowell BB, Kash TL, Rogers JA, Bruchas MR. Neuron. 2015 Sep 2;87(5):1063-77.

Effects of chronic alcohol consumption on neuronal function in the non-human primate BNST. Pleil KE, Helms CM, Sobus JR, Daunais JB, Grant KA, Kash TL. Addict Biol. 2015 Jul 29.

Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala. Pleil KE, Lowery-Gionta EG, Crowley NA, Li C, Marcinkiewcz CA, Rose JH, McCall NM, Maldonado-Devincci AM, Morrow AL, Jones SR, Kash TL. Neuropharmacology. 2015 Jul 16.

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Vardy E, Robinson JE, Li C, Olsen RH, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL. Neuron. 2015 May 20;86(4):936-46.

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Pleil KE, Rinker JA, Lowery-Gionta EG, Mazzone CM, McCall NM, Kendra AM, Olson DP, Lowell BB, Grant KA, Thiele TE, Kash TL. Nat Neurosci. 2015 Apr 18.

Ethanol induced adaptations in 5-HT2c receptor signaling in the bed nucleus of the stria terminalis: implications for anxiety during ethanol withdrawal.Marcinkiewcz CA, Dorrier CE, Lopez AJ, Kash TL. Neuropharmacology. 2015 Feb.; 89:157-67

Functional alterations in the dorsal raphe nucleus following acute and chronic ethanol exposure. Lowery-Gionta EG, Marcinkiewcz CA, Kash TL. Neuropsychopharmacology. 2015 Feb.; 40 (3): 590-600

Neuropeptide regulation of signaling and behavior in the BNST. Kash TL, Pleil KE, Marcinkiewcz CA, Lowery-Gionta EG, Crowley N, Mazzone C, Sugam J, Hardaway JA, McElligott ZA. Mol Cells. 2015 Jan 31;38(1):1-13.

Mechanisms of Neuroplasticity and Ethanol's Effects on Plasticity in the Striatum and Bed Nucleus of the Stria Terminalis. Lovinger DM, Kash TL. Alcohol Res. 2015.

2014

Integrated Circuits and Molecular Components for Stress and Feeding: Implications for Eating Disorders. Hardaway JA, Crowley NA, Bulik CM, Kash TL. Genes Brain Behav. 2014 Nov 4.

Excitatory drive onto dopaminergic neurons in the rostral linear nucleus is enhanced by norepinephrine in an α1 adrenergic receptor-dependent manner. Williams MA, Li C, Kash TL, Matthews RT, Winder DG. Neuropharmacology. 2014 Nov. 86:116-24

Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory. Zhu H, Pleil KE, Urban DJ, Moy SS, Kash TL, Roth BL. Neuropsychopharmacology. 2014 Jul;39(8):1880-92.

2013

Repeated cycles of binge-like ethanol (EtOH)-drinking in male C57BL/6J mice augments subsequent voluntary EtOH intake but not other dependence-like phenotypes.Cox BR, Olney JJ, Lowery-Gionta EG, Sprow GM, Rinker JA, Navarro M, Kash TL, Thiele TE. Alcohol Clin Exp Res. 2013 Oct;37(10):1688-95.

Drinking through the pain. Kash TL, Crabbe JC. Nat Neurosci. 2013 Aug;16(8):987-8.

Repeated Cycles of Binge-Like Ethanol (EtOH)-Drinking in Male C57BL/6J Mice Augments Subsequent Voluntary EtOH Intake But Not Other Dependence-Like Phenotypes. Cox BR, Olney JJ, Lowery-Gionta EG, Sprow GM, Rinker JA, Navarro M, Kash TL, Thiele TE. Alcohol Clin Exp Res. 2013 May 3.

Alcohol effects on synaptic transmission in periaqueductal gray dopamine neurons. Li C, McCall NM, Lopez AJ, Kash TL. Alcohol. 2013 Jun;47(4):279-87.
Distinct extended amygdala circuits for divergent motivational states. Jennings JH, Sparta DR, Stamatakis AM, Ung RL, Pleil KE, Kash TL, Stuber GD. Nature. 2013 Apr 11;496(7444):224-8.

New insights on neurobiological mechanisms underlying alcohol addiction. Cui C, Noronha A, Morikawa H, Alvarez VA, Stuber GD, Szumlinski KK, Kash TL, Roberto M, Wilcox MV. Neuropharmacology. 2013 Apr;67:223-32.

2012

Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. Klug JR, Mathur BN, Kash TL, Wang HD, Matthews RT, Robison AJ, Anderson ME, Deutch AY, Lovinger DM, Colbran RJ, Winder DG. PLoS One. 2012;7(9):e45323

Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding. Holmes A, Fitzgerald PJ, MacPherson KP, DeBrouse L, Colacicco G, Flynn SM, Masneuf S, Pleil KE, Li C, Marcinkiewcz CA, Kash TL, Gunduz-Cinar O, Camp M. Nat Neurosci. 2012 Oct;15(10):1359-61.

The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse. Kash TL. Alcohol. 2012 Jun;46(4):303-8.

Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. Lowery-Gionta EG, Navarro M, Li C, Pleil KE, Rinker JA, Cox BR, Sprow GM, Kash TL, Thiele TE. J Neurosci. 2012 Mar 7;32(10):3405-13.

Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling. Li C, Pleil KE, Stamatakis AM, Busan S, Vong L, Lowell BB, Stuber GD, Kash TL. Biol Psychiatry. 2012 Apr 15;71(8):725-32.

Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Sparrow AM, Lowery-Gionta EG, Pleil KE, Li C, Sprow GM, Cox BR, Rinker JA, Jijon AM, Peňa J, Navarro M, Kash TL, Thiele TE. Neuropsychopharmacology. 2012 May;37(6):1409-21.

Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Pleil KE, Lopez A, McCall N, Jijon AM, Bravo JP, Kash TL. Neuropharmacology. 2012 Mar;62(4):1777-86

2011

β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism. Nobis WP, Kash TL, Silberman Y, Winder DG. Biol Psychiatry. 2011 Jun 1;69(11):1083-90.

2010

Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability. Mozhui K, Karlsson RM, Kash TL, Ihne J, Norcross M, Patel S, Farrell MR, Hill EE, Graybeal C, Martin KP, Camp M, Fitzgerald PJ, Ciobanu DC, Sprengel R, Mishina M, Wellman CL, Winder DG, Williams RW, Holmes A. J Neurosci. 2010 Apr 14;30(15):5357-67.

Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress. McElligott ZA, Klug JR, Nobis WP, Patel S, Grueter BA, Kash TL, Winder DG. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2271-6.

2009

Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalis. Kash TL, Baucum AJ 2nd, Conrad KL, Colbran RJ, Winder DG. Neuropsychopharmacology. 2009 Oct;34(11):2420-9.

2008

Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. Kash TL, Nobis WP, Matthews RT, Winder DG. J Neurosci. 2008 Dec 17;28(51):13856-65.

Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regions. Healey JC, Winder DG, Kash TL. Alcohol. 2008 May;42(3):179-90.

Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis. Kash TL, Matthews RT, Winder DG. Neuropsychopharmacology. 2008 May;33(6):1379-90.

2006

Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis. Kash TL, Winder DG. Neuropharmacology. 2006 Oct;51(5):1013-22.

The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor. Keramidas A, Kash TL, Harrison NL. J Physiol. 2006 Aug 15;575(Pt 1):11-22.

2005

Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis. Egli RE, Kash TL, Choo K, Savchenko V, Matthews RT, Blakely RD, Winder DG. Neuropsychopharmacology. 2005 Apr;30(4):657-68.